Enzymes involed in arachidonic acid release included in the action of steroidogenic hormones in adrenal and leydig cells

MALOBERTI PAULA; CORNEJO MACIEL FABIANA; CASTILLO ANA FERNANDA; CASTILLA ROCÍO; DUARTE ALEJANDRA; TOLEDO M FERNANDA; MEULI FLAVIA; MELE PABLO; PAZ CRISTINA; PODESTÁ ERNESTO J

MOLECULAR AND CELLULAR ENDOCRINOLOGY.

North Holland Publishing

Lugar: Amsterdam, Holanda; Año: 2007 vol. 265 p. 113 - 120

0303-7207

Stimulation of receptors and subsequent signal transduction results in the activation of arachidonic acid (AA) release. Once AA is released from phospholipids or others esters, it may be metabolized via the cycloxygenase or the lipoxygenase pathways. How the cells drive AA to these pathways is not elucidated yet. It is reasonable to speculate that each pathway will have different sources of free AA triggered by different signal transduction pathways. Several reports have shown that AA and its lipoxygenase-catalyzed metabolites play essential roles in the regulation of steroidogenesis by influencing cholesterol transport from the outer to the inner mitochondrial membrane, the rate-limiting step in steroid hormone biosynthesis. Signals that stimulate steroidogenesis also cause the release of AA from phospholipids or other esters by mechanisms that are not fully understood. This review focuses on the enzymes of AA release that impact on steroidogenesis.