BIODEGRADABLE MICROSPHERES OF POLY(DL-LACTIDE) CONTAINING PROGESTERONE

CHIAPPETTA D.A.; LEGASPI M.J.; NISELMAN V.; PASQUALI R.C.; GERGIC E.P.; RODRIGUEZ LLIMÓS A.C.; BREGNI C.

ARS PHARMACEUTICA

FACULTAD DE FARMACIA DE LA UNIVERSIDAD DE GRANADA

Lugar: GRANADA; Año: 2005 vol. 46 p. 383 - 398

0004-2927

Microspheres of poly(D,L-lactide) containing progesterone were prepared by the solvent evaporation method using a simple oil water emulsion. 23 factorial design was used to determine the effect of three independent variables (amount of drug, amount of polymer and concentration of polyvinyl alcohol) over the dependent variables (drug content and particle size). The three independent variables influenced significantly over the percentage drug encapsulated. On the other hand, in the particle size case, the variables which produced a significantly influence were the polyvinyl alcohol concentration and the amount of polymer. The in vitro release studies have shown that according to the particle size, it can be obtained formulations which are able to release progesterone in a few days or a sustained release among 28 days. The physical state of drug has been examined by differential scanning calorimetric. The studies indicate that exists a physicochemical interaction between the progesterone and the polymer.