Gibbs energy of transfer processes for the antimicrobial agent Triclosan from water to some organic solvents at 25.0 °C

ARAGON D.M.; CHIAPPETTA D.A.; DEGROSSI J.; VARGAS E.F.; BREGNI C.; SOSNIK A.; MARTINEZ F.

Revista Colombiana de Ciencias Quimico Farmaceuticas

Facultad de Ciencias, Universidad Nacional de Colombia

Año: 2008 vol. 37 p. 241 - 257

0034-7418

The thermodynamic function Gibbs energy for the dissolution processes of triclosan (TS) was calculated from solubility values obtained at 25.0 °C in organic solvents with different hydrogen-bonding capability. TS solubility was determined in ethanol, octanol, water-saturated octanol, isopropyl myristate, chloroform, and heptane. The excess Gibbs energy and the activity coefficients of the solute were also calculated. In addition, the corresponding Gibbs energies of the drug transfer process from water to the organic solvents under investigation were also calculated by means of previous reports. In all cases, this thermodynamic property comprised a negative value, indicating the preference of TS for all the organic media evaluated.