INVESTIGADORES
CHIAPPETTA Diego Andres
artículos
Título:
Micro/Nanostructured Hyaluronic Acid Matrices with Tuned Swelling and Drug Release Properties.
Autor/es:
MINABERRY Y.; CHIAPPETTA D.A.; SOSNIK A.; JOBAGGY M.
Revista:
BIOMACROMOLECULES
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2013 vol. 14 p. 1 - 9
ISSN:
1525-7797
Resumen:
Hyaluronic acid (HA) hydrogels were structured in the form of porous monoliths by means of the ice-segregation-induced self-assembly (ISISA) method coupled with freeze−drying. Physical and chemical parameters were explored in order to fine-tune the microstructure and the incidence on both swelling and dissolution behavior in aqueous media. Gentamicin-loaded HA matrices with tuned drug release properties were also prepared; their inherent properties and behavior in solution are discussed in the framework of thermal analysis and scanning electron microscopy inspection.
