PERSONAL DE APOYO
BARBISAN Gisela
artículos
Título:
TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk.
Autor/es:
BARBISAN G; PÉREZ LO; CONTRERAS A; GOLIJOW CD
Revista:
TUMOR BIOLOGY
Editorial:
KARGER
Referencias:
Lugar: Basel; Año: 2012 vol. 33 p. 1549 - 1556
ISSN:
1010-4283
Resumen:
Although the implication of genetic factors in
cervical cancer development remains to be elucidated, accumulative
epidemiological evidence suggests that polymorphisms
of cytokine genes may be involved in the
etiology of cervical carcinoma. Tumor necrosis factor alpha
(TNF-α) and interleukin-10 (IL-10) are two multifunctional
cytokines implicated in inflammation, immunity, and cellular
organization, and were proposed to play important roles
in cancer biology. In order to determine whether IL-10 -
1082 (G/A) and TNF-α -238 (G/A) and -308 (G/A) polymorphisms
are associated with susceptibility to cervical
cancer, a casecontrol study of 122 cancer patients and
176 healthy controls was conducted. Cervical samples were
genotyped for both TNF-α polymorphisms by PCR-RFLP
assay. SNP-1082 from IL-10 gene was genotyped using pyrosequencing
technology. The association between cervical cancer
risk and the studied SNPs was evaluated by logistic
regression. Under univariate analysis, none of these polymorphisms
appeared associated with susceptibility of cervical
cancer development or HPV infection. However, individuals
carrying heterozygous genotype for TNF-α -238 polymorphism
seem to be at lower risk for cervical cancer development,
with borderline significance (OR00.42, P00.069), as
well as those carrying heterozygous genotypes for IL-10 and
TNF-α -238 (OR00.40, P00.08). In conclusion, these results
suggest a potential effect of TNF-α -238 G/A in the reduction
of cervical cancer risk in Argentine women, but not TNF-α -
308 or IL-10. Larger studies are needed to fully understand the
genetic predisposition for the development of cervical cancer.