Influence of TNF and IL6 gene polymorphisms on the severity of cytopenias in argentine patients with Myelodysplastic Syndromes

BESTACH, YESICA; PALAU NAGORE, MARÍA VIRGINIA; FLORES, GABRIELA; GONZALEZ, JACQUELINE; ARBELBIDE, JORGE; WATMAN, NORA; SIEZA, YAMILA; LARRIPA, IRENE; BELLI, CAROLINA

ANNALS OF HEMATOLOGY

SPRINGER

Lugar: Berlin; Año: 2017 vol. 96 p. 1287 - 1295

0939-5555

Myelodysplastic syndromes (MDS) represent a heterogeneous group of hematologic disorders characterized by cytopenia(s) and predisposition to leukemic progression. An immune dysregulation and an aberrant bone marrow microenvironment seem to be key elements in the physiopathological process of MDS. In order to evaluate a possible association between susceptibility and clinic-pathologic features, we genotyped 153 MDS patients for functional cytokine polymorphisms: TNF (-308 G/A), IFNG (+874 A/T and +875 CAn), IL6 (-174 G/C), and TGFB1 (+869 C/T and +915 G/C). The frequency of TNF and IL6 polymorphisms was different between patients and healthy controls(n=131), suggesting a relatedness to MDS susceptibility in our population.Furthermore, the presence of each or both high-producing genotypes [TNF: p=0.048, odds ratio (OR): 3.979; IL6: p=0.001, OR: 6.835; both: p=0.010, OR: 6.068] and thrombocytopenia at platelet counts of