NEUROPROTECTIVE EFFECTS OF BIOAVAILABLE PHENOLIC COMPOUNDS FROM ILEX PARAGUARIENSIS ON THE BRAIN OF MICE WITH LUNG ADENOCARCINOMA

CITTADINI MC; REPOSSI G; ALBRETCH C; DI PAOLA NARANJO R; MIRANDA AR; DE PASCUAL-TERESA S; SORIA EA

Córdoba

Congreso; VII Congreso Internacional de Ciencia y Tecnología de los Alimentos; 2018

Ministerio de Ciencia y Tecnología de la Prov. de Córdoba

Lung carcinoma is one of the most common cancers and has a high mortality.Recently, we showed that it produces neurological paraneoplastic syndrome,with Ilex paraguariensis extract (IP) exerting palliative effects due to its contentof phenolic compounds. It is possible, therefore, that these diet agents canarrive at the brain and exert neuroprotection, after the oral intake of IP. Here,the aim was to investigate the protective role of bioavailable IP compounds onthe telencephalon and diencephalon in lung adenocarcinoma-bearing BALB/cJmales. Mice aged 2-months were treated for 3 weeks with 0-100 IP mg/Kg/day.HPLC-UV revealed the presence of chlorogenic acid and quercetin in brainregions, liver and tumour, and at other sites in an IP dose-dependent manner.Brain was also evaluated histologically, and IL-6 was measured by ELISA.Chlorogenic acid was the major compound found in brain, whereas quercetinwas observed at the diencephalon to a lesser extent. Both compounds wereinvolved in IP dose-dependent diencephalic interleukin-6 reduction. Histologysuggested cellular neuroprotection with less apoptosis in chlorogenic-exposedareas. Taken together, chlorogenic acid and quercetin from dietary IP werebioavailable and bioactive in brain, thereby attenuating lung cancer-relatedneuroinflammation and damage. These findings support plant-based strategiesto improve prognosis.