INVESTIGADORES
ROGBERG MUÑOZ Andres
artículos
Título:
Longitudinal analysis of the effects of IGF1-SnaBI genotypes on the growth curve of Angus bull calves
Autor/es:
ROGBERG MUÑOZ A; CANTET RJC; FERNANDEZ ME; LIRÓN JP; PRANDO A; BIRCHMEIER AN; RIPOLI MV; GIOVAMBATTISTA G
Revista:
LIVESTOCK SCIENCE
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 154 p. 55 - 59
ISSN:
1871-1413
Resumen:
The Insulin Growth Factor 1 (IGF1) has been proposed as a
candidate gene for growth related traits as it plays a central role in
growth and development of mammals. A relationship between serum IGF1
concentration and different growth traits in cattle has been documented.
Furthermore, the IGF1-SnaBI SNP in the gene promoter
region influences gene expression and IGF1 blood level. The current
research was conducted to perform a genetic analysis of longitudinal
data for growth curves through the evaluation of the influence of IGF1-SnaBI
genotypes on the growth curve of beef cattle during highly anabolic
stages. Data were taken on 275 Angus bull calves on two consecutive
years, in two commercial cowcalf operations. Calves were weighed at
birth, at weaning, and at 3 to 4 times before the year of age. A random
regression animal model was employed for the analysis. Fixed effects
were age of dam, herd-year, and age of calf (linear and quadratic terms
nested within IGF1-SnaBI genotype). Random effects were
age at measure (linear and a quadratic terms nested within animal). The
analysis showed significant differences (P<0.01) in the growth curves at ages in between 66 and 291 days for the IGF1-SnaBI genotypes. At 210 days of age, the effect of substituting a T by a C was estimated to be 5.21kg. These results suggest that the effect of IGF1-SnaBI over growth in cattle take place mostly before puberty.