INVESTIGADORES
LO PRESTI Maria Silvina
artículos
Título:
Mitochondrial involvement in chronic chagasic cardiomyopathy
Autor/es:
BAEZ AL; LO PRESTI MS; RIVAROLA HW; GUZMAN MENTESANA G; PONS P; FRETES R; PAGLINI PA
Revista:
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Año: 2011 vol. 105 p. 239 - 246
ISSN:
0035-9203
Resumen:
The pathogenesisofchronicchagasiccardiopathyisstillunderdiscussion;thereiscon- siderable evidencethatinflammatoryinfiltratesandtheirmediatorshaveadirecteffect on cardiaccells.Herewestudiedthestructureandfunctionofcardiacmitochondriain chronic chagasicmyocardiopathy.Cardiacmitochondrialstructureandenzymeactivity of citratesynthaseandcomplexesItoIVoftherespiratorychainwerestudiedinalbino Swiss miceinfectedwith Trypanosoma cruzi (Tulahuen strainorSGOZ12isolate)on365 days post-infection(dpi).Thepresenceofparasitesincardiacandskeletalmusclewasalso investigated. TheactivityofcomplexesItoIVwasalteredindifferentways,accordingto the strainemployed(P <0.0001),inrelationtothecristaedisorganisationandtheparasite persistence foundintheTulahuengroup,andthechronicinflammatoryprocessdescribed in bothgroups;citratesynthaseactivityalsoincreasedinbothinfectedgroups.Changesin mitochondrial structureweredetectedin89%ofTulahuen-and58%ofSGOZ12-infected mice. Inthispaperwedemonstratethatparasitepersistenceandinflammationarelikelyto be involvedinthestructuralandfunctionalalterationsincardiacmitochondriafromchron- ically T. cruzi-infected mice,demonstratingthattheparasitestraindeterminesdifferent mitochondrial changesinchagasiccardiopathy. Trypanosoma cruzi (Tulahuen strainorSGOZ12isolate)on365 days post-infection(dpi).Thepresenceofparasitesincardiacandskeletalmusclewasalso investigated. TheactivityofcomplexesItoIVwasalteredindifferentways,accordingto the strainemployed(P < 0.0001),inrelationtothecristaedisorganisationandtheparasite persistence foundintheTulahuengroup,andthechronicinflammatoryprocessdescribed in bothgroups;citratesynthaseactivityalsoincreasedinbothinfectedgroups.Changesin mitochondrial structureweredetectedin89%ofTulahuen-and58%ofSGOZ12-infected mice. Inthispaperwedemonstratethatparasitepersistenceandinflammationarelikelyto be involvedinthestructuralandfunctionalalterationsincardiacmitochondriafromchron- ically T. cruzi-infected mice,demonstratingthattheparasitestraindeterminesdifferent mitochondrial changesinchagasiccardiopathy.
