INVESTIGADORES
RAMALLO Ivana Ayelen
artículos
Título:
A Bioactive Trypanosoma cruzi Bromodomain Inhibitor from Chemically Engineered Extracts
Autor/es:
RAMALLO, IVANA AYELEN; ALONSO, V; RUA, F; SERRA, E; FURLAN, RLE
Revista:
ACS Combinatorial Science
Editorial:
ACS
Referencias:
Lugar: Washington; Año: 2018 vol. 20 p. 220 - 228
ISSN:
2156-8952
Resumen:
A set of chemically engineered extracts enriched in compounds including N−N and N−O fragments in their11 structures was prepared. Bromodomain binding screening and bioguided fractionation led to the identification of one oxime hit12 that interacts with TcBDF3 with affinity in the submicromolar range and that shows interesting antiparasitic properties against13 the different life cycle stages of T. cruzi
