Proteome analysis of BP1092 – a potential new virulence factor regulator in Bordetella pertussis

KRISTIN SURMANN; DEBANDI, MARTINA; CARRICA MARIELA; CHRISTIAN HENTSCHKER; RODRIGUEZ, MARÍA EUGENIA; UWE VÖLKER; LAMBERTI, YANINA ANDREA

Busan

Congreso; HUPO World Congress 2023; 2023

HUPO Human Proteomics Organization

Virulence factors play a key role in Bordetella pertussis (Bp) persistence inside host cells. Virulence factor expression in Bp is controlled by the interrelated two-component systems (TCS) BvgAS and RisAK. There are hints that further, yet unknown, regulatory systems might be involved, too. Thus, BP1092, a TCS histidine kinase, which displays increased protein levels upon internalization by a human macrophage cell line [1, is an interesting candidate for more detailed analysis.Our data of B. pertussis infection-mimicking models suggest that BP1092 plays a crucial role in fine-tuning of virulence factor levels after infection with an impact on intracellular survival.