Non specific inmunomodulation combined with enrofloxacin in the treatment of endometritis mares

FUMUSO E; CEBALLOS, L; GONZALEZ C; MORENO, L; WADE J; VIDELA DORNA I; ROGAN D; SANCHEZ BRUNI, S

Ottawa, Canada.

Conferencia; 2nd Conference of Antimicrobial Agents in Veterinary Medicine; 2004

NON -SPECIFIC IMMUNOMODULATION COMBINED WITH ENROFLOXACIN IN THE TREATMENT OF ENDOMETRITIS IN MARES. Fumuso E1., Ceballos L1., González C.1, Moreno, L.1,. Videla Adorna I., Wade, J.2, Rogan, D.2; Sánchez Bruni,S1. 1 Pharmacology Laboratory, Faculty of Veterinary Medicine., Universidad Nacional del Centro- Tandil (7000)Argentina, 2-Bioniche Animal Health, Canada.  ssanchez@vet.unicen.edu.ar A more novel approach to thinking of the beneficial aspects of the antimicrobial’s intracellular accumulation is to view the cell as a “drug delivery device”. Mobile phagocytes are accumulated at the site of infections and seem to be a practical vehicle to deliver concentrations of fluorquinolones and macrolides into the infected tissue. The main goal of this trial was to evaluate the efficacy of the combination of enrofloxacin (EFX) and a non-specific immunomodulator of Mycobacterium phlei cell wall complex (Equimune ®) on the clinical treatment of mares’ endometritis. Fifteen natural infected cross-breed mares were allocated in three groups (n=5), according bacteriological and clinical scores and treated as follows: Group (G) I received one intravenous (IV) dose of Equimune® at 7am and 5 mg/kg of EFX IV at 4 h pm (time 0), the G II received one IV dose of Equimune® and 5 mg/kg of EFX IV given at time 0 and the G III received an IV dose of 5 mg/kg of EFX at time 0. Samples for bacteriological culture and cytology studies were taken pre (0h) and 48 h post-treatment. Bacterial cultures were blood agar and Eeosin Blue. Data were analysed by a contingence table using Fisher Exact Test. The treatment assayed for the GI shown over 80% of efficacy with bacteriological cure in comparison with results obtained for the GII and III (20% and 40% of efficacy, respectively). This treatment combination could be a new option for treatment of mares’ endometritis in terms of clinical practice