Efficacy and safety of albendazole and high-dose ivermectin co-administration in school-aged children infected with Trichuris trichiura in Honduras: A Randomized Controlled Trial

MATAMOROS, GABRIELA; SÁNCHEZ, ANA; GABRIE, JOSÉ ANTONIO; JUÁREZ, MARISA; CEBALLOS, LAURA; ESCALADA, ANDRÉS; RODRÍGUEZ, CAROL; MARTÍ-SOLER, HELENA; RUEDA, MARÍA MERCEDES; CANALES, MARITZA; LANUSSE, CARLOS; CAJAL, PAMELA; ÁLVAREZ, LUIS; CIMINO, RUBÉN O; KROLEWIECKI, ALEJANDRO

CLINICAL INFECTIOUS DISEASES

UNIV CHICAGO PRESS

Lugar: Chicago; Año: 2021

1058-4838

The efficacy of currently available anthelminthics against Trichuris trichiura infections issignificatively lower than for other soil-transmitted helminths (STH). The combination of ivermectin (IVM) and albendazole (ALB) has shown significant improvements in efficacy. Methods Safety and efficacy randomized controlled clinical trial comparing 3 experimental regimens against ALB monotherapy for the treatment of T. trichiura infections in northern Honduras. Infected children were randomized to one of the following treatments: (Arm 1) single-dose ALB 400 mg; (Arm 2) single-dose ALB 400 mg/IVM 600 μg/kg; (Arm 3) ALB 400 mg for 3consecutive days; or (Arm 4) ALB 400 mg/IVM 600 μg/kg for 3 consecutive days. Efficacywas measured through egg reduction rate (ERR) and cure rate (CR), both assessed 14-21 daysafter treatment using the Kato-Katz method. Safety was evaluated by analyzing the frequency