INVESTIGADORES
CEBALLOS Laura
artículos
Título:
Flubendazole in cystc echinococcosis therapy: pharmaco-parasitological evaluation in mice
Autor/es:
CEBALLOS, L; ELISSONDO, M; SANCHEZ BRUNI, S; DENEGRI, G; ALVAREZ, L; LANUSSE, C
Revista:
PARASITOLOGY INTERNATIONAL
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Año: 2009 p. 354 - 358
ISSN:
1383-5769
Resumen:
Abstract: Cystic echinococcosis (CE) caused by the parasite Echinococcus granulosus is an
important public health problem worldwide. Flubendazole has shown poor in vivo efficacy against
CE in humans and mice. However, flubendazole causes marked in vitro damage on E. granulosus
protoscoleces. The goals of the current work were: a) to compare the plasma pharmacokinetic
behaviour of flubendazole formulated as a hydroxipropyl-â-cyclodextrin aqueous solution or as a
carboxymethylcelullose suspension, both given by the oral route to mice, b) to compare
flubendazole clinical efficacy in secondary CE in mice after its administration as both formulations,
c) to evaluate the flubendazole-induced morphological changes in hydatid cysts recovered from
infected mice treated with both drug formulations. Flubendazole administration as a solution
resulted in significantly higher plasma maximum concentration (Cmax) and area under the
concentration-time curve (AUC) values compared to those obtained after the flubendazolesuspension
treatment. This enhanced drug availability correlated with an increased efficacy against
secondary CE in mice observed for the flubendazole-solution formulation, while the suspension
formulation did not reach differences with the untreated control group. Similar ultrastructural
changes were observed in cysts recovered from flubendazole (both formulations) treated mice after
3, 6 and 9 months of infection, although the damage extension was greater after treatment with the
flubendazole-solution formulation.