INVESTIGADORES
CEBALLOS Laura
artículos
Título:
Dose-dependent systemic exposure of albendazole metabolites in lambs
Autor/es:
ALVAREZ, L; SUAREZ, G; CEBALLOS, L; MORENO TORREJÓN, L.; LANUSSE, C
Revista:
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2011
ISSN:
0140-7783
Resumen:
The gastrointestinal absorption of most drugs follows a first-order kinetics,
whereby a constant fraction of the total drug is absorbed in each equal time
interval. Although this related absorption principle is applicable to the most of
the therapeutically used drugs, it remains unclear for poorly water-soluble
compounds such as the benzimidazole anthelmintics in ruminants. The goal of
the current work was to characterize the albendazole (ABZ) metabolites plasma
disposition kinetics after ABZ administration at different dosages to nematodeinfected
lambs. Eighteen Corriedale lambs artificially infected with a resistant
Haemonchus contortus strain were allocated into three groups and intraruminally
treated with ABZ at either five (ABZ5), 15 (ABZ15) or 45 (ABZ45) mg⁄ kg.
Blood samples were collected up to 120 h post-treatment, and the collected
plasma was analysed by high-performance liquid chromatography. The
estimated pharmacokinetic parameters were statistically compared using
parametric and nonparametric tests. None of the animals involved in the
current trial showed any adverse events during the study. While ABZ parent
drug was not recovered in the bloodstream, the area under the concentration vs
time curve (AUC) of the active ABZ-sulphoxide (ABZSO) metabolite increased
significantly (P < 0.05) from 21.0 (ABZ5) up to 158.6 (ABZ15) and
389.7 lgÆh⁄ mL (ABZ45), which indicates some type of nonproportionality in
the relationship between dose level and drug systemic exposure. The overall
kinetic disposition of the inactive sulphone metabolite did not change after
treatment at threefold the therapeutic ABZ dosage. However, significantly
(P < 0.05) higher AUC, Cmax and mean residence time values were observed
after the administration of the highest dosage level. The higher dosages
accounted for a significantly (P < 0.05) enhancement of the ABZSO peak
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
after the administration of the highest dosage level. The higher dosages
accounted for a significantly (P < 0.05) enhancement of the ABZSO peak
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
the relationship between dose level and drug systemic exposure. The overall
kinetic disposition of the inactive sulphone metabolite did not change after
treatment at threefold the therapeutic ABZ dosage. However, significantly
(P < 0.05) higher AUC, Cmax and mean residence time values were observed
after the administration of the highest dosage level. The higher dosages
accounted for a significantly (P < 0.05) enhancement of the ABZSO peak
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
after the administration of the highest dosage level. The higher dosages
accounted for a significantly (P < 0.05) enhancement of the ABZSO peak
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
389.7 lgÆh⁄ mL (ABZ45), which indicates some type of nonproportionality in
the relationship between dose level and drug systemic exposure. The overall
kinetic disposition of the inactive sulphone metabolite did not change after
treatment at threefold the therapeutic ABZ dosage. However, significantly
(P < 0.05) higher AUC, Cmax and mean residence time values were observed
after the administration of the highest dosage level. The higher dosages
accounted for a significantly (P < 0.05) enhancement of the ABZSO peak
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
after the administration of the highest dosage level. The higher dosages
accounted for a significantly (P < 0.05) enhancement of the ABZSO peak
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
the relationship between dose level and drug systemic exposure. The overall
kinetic disposition of the inactive sulphone metabolite did not change after
treatment at threefold the therapeutic ABZ dosage. However, significantly
(P < 0.05) higher AUC, Cmax and mean residence time values were observed
after the administration of the highest dosage level. The higher dosages
accounted for a significantly (P < 0.05) enhancement of the ABZSO peak
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
after the administration of the highest dosage level. The higher dosages
accounted for a significantly (P < 0.05) enhancement of the ABZSO peak
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
Blood samples were collected up to 120 h post-treatment, and the collected
plasma was analysed by high-performance liquid chromatography. The
estimated pharmacokinetic parameters were statistically compared using
parametric and nonparametric tests. None of the animals involved in the
current trial showed any adverse events during the study. While ABZ parent
drug was not recovered in the bloodstream, the area under the concentration vs
time curve (AUC) of the active ABZ-sulphoxide (ABZSO) metabolite increased
significantly (P < 0.05) from 21.0 (ABZ5) up to 158.6 (ABZ15) and
389.7 lgÆh⁄ mL (ABZ45), which indicates some type of nonproportionality in
the relationship between dose level and drug systemic exposure. The overall
kinetic disposition of the inactive sulphone metabolite did not change after
treatment at threefold the therapeutic ABZ dosage. However, significantly
(P < 0.05) higher AUC, Cmax and mean residence time values were observed
after the administration of the highest dosage level. The higher dosages
accounted for a significantly (P < 0.05) enhancement of the ABZSO peak
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
after the administration of the highest dosage level. The higher dosages
accounted for a significantly (P < 0.05) enhancement of the ABZSO peak
plasma concentration, which were obtained at delayed times post-treatment.
High correlations between AUC0-LOQ and Cmax and nematode counts were
observed, with Spearmans coefficients of )0.83 and )0.84, respectively. The
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.
The data showed a nonproportionality on the gastrointestinal absorption of
ABZ in nematode-infected lambs.
results obtained in the current experiment show that increasing the dose of ABZ
in sheep is clearly associated with enhanced plasma ABZ metabolites exposure.