DEPRESSION-RELATED ABNORMALITIES IN CIRCADIAN RHYTHM OF CARDIAC AUTONOMIC ACTIVITY IN SURVIVORS OF ACUTE CORONARY SYNDROMES

MARÍA S. LADRÓN DE GUEVARA; MARIANA N. CASTRO; DANIEL E. VIGO; GUSTAFSON D; VILA PÉREZ I; MASSARO P; MONTOYO J; FIGUERAS BELLOT J; CARDINALI DP; GUINJOAN S

Congreso; 15th World Congress of Psychiatry; 2011

We sought to characterize the influence of depression on the circadian pattern of cardiac autonomic activity, a known independent predictor of adverse outcomes six months after an acute coronary syndrome (ACS), in 102 patients. They were studied with a clinical interview, a 21-item Hamilton Depression Scale, and a 24h recording of heart rate variability (HRV) at admission and at six months. HRV was measured during wake and sleep (11PM-7AM) with a fast Fourier transform algorithm. We measured meanRR (mRR); low-frequency HRV (LF, LFnu) influenced by both sympathetic and parasympathetic activity; high-frequency HRV (HF, HFnu)determined by parasympathetic activity; and LF/HF ratio indicating the sympathovagal balance (LF/HF). At admission depression had a prevalence of 44%, and was associated with higher mRR, that is higher heart rate, during sleep (p