INVESTIGADORES
FERNANDEZ LARROSA Pablo Nicolas
artículos
Título:
The nuclear receptor coactivator RAC3 inhibits autophagy
Autor/es:
P. N. FERNÁNDEZ LARROSA; C. ALVARADO; M.F. RUBIO; M. RUIZ GRECCO; S. MICENMACHER; G. MARTINEZ NOEL; L. PANELO; M. COSTAS
Revista:
CANCER SCIENCE
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2012 vol. 103 p. 2064 - 2071
ISSN:
1347-9032
Resumen:
RAC3 is an oncogene naturally overexpressed in several tumors.Besides its role as coactivator, it can exert several protumoralcytoplasmic actions. Autophagy was found to act either as atumor suppressor during the early stages of tumor development,or as a protector of the tumor cell in later stages under hypoxicconditions. We found that RAC3 overexpression inhibits autophagywhen induced by starvation or rapamycin and involvesRAC3 nuclear translocation-dependent and -independent mechanisms.Moreover, hypoxia inhibits the RAC3 gene expressionleading to the autophagy process, allowing tumor cells to surviveuntil angiogenesis occurs. The interplay between RAC3, hypoxia,and autophagy could be an important mechanism for tumorprogression and a good target for a future anticancer therapy.
