INVESTIGADORES
BOSQUIAZZO Veronica Lis
artículos
Título:
Effects of neonatal exposure to bisphenol A on steroid regulation of vascular endothelial growth factor expression and endothelial cell proliferation in the adult rat uterus.
Autor/es:
BOSQUIAZZO VL, VARAYOUD J, MUÑOZ-DE-TORO M, LUQUE EH, RAMOS JG.
Revista:
BIOLOGY OF REPRODUCTION
Editorial:
SOC STUDY REPRODUCTION
Referencias:
Año: 2010 p. 86 - 95
ISSN:
0006-3363
Resumen:
Hormonally controlled vascular changes play a key role in
endometrial development and in the differentiation process
necessary for implantation. Vascular endothelial growth factor
(VEGF) has emerged as one of the central regulators of the
uterine vasculature. Hormonal perturbations during neonatal
development may alter sex steroid-dependent regulation of
VEGF and may ultimately affect fertility later in life. The aim of
this study was to determine whether neonatal exposure to the
environmental estrogenic chemical bisphenol A (BPA) affects the
adult rat uterine response to hormonal stimuli. Newborn female
rats were given s.c. injections of vehicle, BPA (0.05 mg/kg per
day or 20 mg/kg per day) or diethylstilbestrol (0.2 lg/kg per day)
on Postnatal Days 1, 3, 5, and 7. To evaluate the long-term
effects, rats were ovariectomized at Postnatal Day 80 and
submitted to hormonal replacement. Rats neonatally exposed to
xenoestrogens showed a decreased induction of uterine endothelial
proliferation and a decreased Vegf mRNA expression in
response to ovarian steroid treatment. Also, although the
estrogen receptor alpha (ESR1) expression was lower in
subepithelial cells than in controls, a higher expression of
silencing mediator of retinoic acid and thyroid hormone
receptor (NCOR1, also known as SMRT) corepressor was
evidenced in the same compartment. The results indicate that
disturbed Vegf expression in BPA rats could be the result of
changes in endocrine pathways, such as an altered induction of
ESR1 and/or NCOR1 expression. Because of the importance of
VEGF in the implantation process, our data suggest that neonatal
BPA exposure might have negative consequences on female
fertility.