INVESTIGADORES
BRUNO Martin Alejandro
artículos
Título:
The Failure in NGF Maturation and its Increased Degradation as the Probable Cause for the Vulnerability of Cholinergic Neurons in Alzheimers Disease
Autor/es:
CUELLO AC AND BRUNO MA
Revista:
NEUROCHEMICAL RESEARCH
Referencias:
Año: 2006 p. 1718 - 1722
ISSN:
0364-3190
Resumen:
This short review discusses the arguments to
consider the dismetabolism of the pathway responsible
for both the maturation and degradation of NGF as the
culprit of vulnerability of the forebrain cholinergic
system to the Alzheimers disease neuropathology.
This summary includes information regarding a novel
metabolic cascade converting Pro-NGF to mature NGF
in the extracellular space and its ultimate degradation
by a metalloprotease. It also describes how this pathway
is altered in Alzheimers disease with the consequential
CNS accumulation of proNGF and impairment in the
formation of NGF along with increased degradation of
this key trophic factor. This metabolic scenario in
Alzheimers disease should result in the failure of NGF
trophic support to forebrain cholinergic neurons and
thus explaining the vulnerability of these neurons in this
neurodegenerative condition.