Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c

CAPDEVILA, D.A.; ALVAREZ PAGGI, D.; CASTRO M.A.; TÓRTORA V.; DEMICHELI V.; ESTRIN, D.A.; RADI, R.; MURGIDA, D.H.

CHEMICAL COMMUNICATIONS

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2014 vol. 50 p. 2592 - 2594

1359-7345

Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH.