Formulation of casein films composed of tetracaine hydrochloride for use as potential a local anesthetic system in dentistry

YAMILE SOLEDAD AON; CRISTIAN ALEJANDRO FERRETTI; LEANDRO GABRIEL GUTIÉRREZ; CANDELA BORELLO; VANINA ALEJANDRA GUNTERO; MARÍA CANDELA ACUÑA

San Francisco

Jornada; Jornadas de Ciencia y Tecnología 2022 de la Universidad Tecnológica Nacional, Facultad Regional San Francisco; 2022

Secretaría de Ciencia y Tecnología, Facultad Regional San Francisco

In the present study, it was proposed to synthesize a film that incorporates tetracaine hydrochloride as an active compound, since it is widely used in medicine for its anesthetic property. In the proposed formulations was used a natural polymer, casein, and in addition, compounds such as glycerol and potassium alginate were added in order to modify certain mechanical and physical properties. In this way, various experiments were carried out, varying the amounts of each component until the film reached the desired Characteristics. The film TC3 was acceptable, so it was subjected to a series of tests to characterize it. Among the tests carried out are the determination of thickness, moisture content, total soluble material and insoluble solid. From the results obtained, we can conclude that the formulation of the developed film could have a potential use as a local anesthetic in odontology.