Synthesis and Encapsulation of bis-eugenol in a Mesoporous Solid Material: Enhancement of the Antioxidant Activity of a Natural Compound from Clove Oil

FERRETTI CRISTIÁN ALEJANDRO; GUNTERO, VANINA ALEJANDRA; KNEETEMAN MARÍA; MANCINI PEDRO

Chemical Science International Journal

SCIENCEDOMAIN international

Año: 2018 vol. 22 p. 1 - 10

2456-706X

In the present work, microwave extraction conditions to recover high eugenol content in the crude extract from clove were investigated. The effect of factors like temperature, stirring, time, liquid: Solid ratio and solutions of solvent were evaluated with Taguchi?s method. The eugenol content was determined by gas chromatography. From the isolated eugenol, the bis-phenol was synthesized by the dimerization of eugenol. The encapsulation of bis-eugenol on the mesoporous silica was carried out by a microwave assisted process. Previously, mesoporous silica SBA-15 was prepared by hydrothermal synthesis using Pluronic P123 triblock copolymer as a surfactant. The bis-eugenol encapsulated in SBA-15 was characterized by physicochemical techniques. The results indicated that the encapsulation of bis-eugenol in the pores of silica occurred through weak interactions of an electrostatic nature without producing chemical changes in the antioxidant property. The antioxidative activity of eugenol, bis-eugenol and bis-eugenol/SBA-15 system was examined by phosphomolybdenum assay. Among these materials, a remarkably high antioxidant activity was found in bis-eugenol encapsulated in SBA-15. These resultas suggest the possibility of applying this system as an antioxidant active packaging in the future.