Epidemiology of anomalies of proliferation

KAUFFMAN MARCELO; CONSALVO DAMIAN; SALGADO PABLO; SICA ROBERTO; KOCHEN SILVIA

Santiago de Chile

Congreso; 11 Congreso Panamericano de Neurologìa; 2003

Introduction: Malformations of cortical development (MCD) are a heterogeneous group of diseases causing epilepsy. MRI studies classify the MCD in different nosological entities. Objectives: To compare clinical characteristics, EEG and MRI of epileptic patients with diagnosis of tuberous sclerosis (TS)(G1), focal transmantle dysplasia (FTD)(G2) and focal non-transmantle dysplasia (FNTD) (G3). Methods: We compared the variables age, sex, age at first seizure (A1S), mental retardation (MR), antecedent of pregnancy or perilabour trauma (PT), annual seizure frequency (ASF), response to treatment and epileptogenic zone between the three groups. Results: G1 (n = 9) average age 25F4 years MR in five A1S 2.38F5.18, PT in two ASF 80.5F113.8; G2 (n = 10) average age 38F14 years MR in one AIS 12.10F8.9, PT in one ASF 238.6F279.9; G3 (n = 13) average age 32F15 years MR in zero AIS 16.6F17.4, PT in seven ASF 81.7F119.25. MR and A1C set apart G1 from the other groups ( p = 0.003 and p = 0.045). PT set apart G3 rom G2 ( p = 0.038). There are no differences between the other variables analyzed. Conclusions: TS and focal cortical dysplasias have different clinical characteristics. The occurrence of trauma during the development seems to be more important in FNTD than in FTD.: Malformations of cortical development (MCD) are a heterogeneous group of diseases causing epilepsy. MRI studies classify the MCD in different nosological entities. Objectives: To compare clinical characteristics, EEG and MRI of epileptic patients with diagnosis of tuberous sclerosis (TS)(G1), focal transmantle dysplasia (FTD)(G2) and focal non-transmantle dysplasia (FNTD) (G3). Methods: We compared the variables age, sex, age at first seizure (A1S), mental retardation (MR), antecedent of pregnancy or perilabour trauma (PT), annual seizure frequency (ASF), response to treatment and epileptogenic zone between the three groups. Results: G1 (n = 9) average age 25F4 years MR in five A1S 2.38F5.18, PT in two ASF 80.5F113.8; G2 (n = 10) average age 38F14 years MR in one AIS 12.10F8.9, PT in one ASF 238.6F279.9; G3 (n = 13) average age 32F15 years MR in zero AIS 16.6F17.4, PT in seven ASF 81.7F119.25. MR and A1C set apart G1 from the other groups ( p = 0.003 and p = 0.045). PT set apart G3 rom G2 ( p = 0.038). There are no differences between the other variables analyzed. Conclusions: TS and focal cortical dysplasias have different clinical characteristics. The occurrence of trauma during the development seems to be more important in FNTD than in FTD.