INVESTIGADORES
ZOPPINO Felipe Carlos Martin
artículos
Título:
SPINK7 expression changes accompanied by HER2, P53 and RB1 can be relevant in predicting oral squamous cell carcinoma at a molecular level
Autor/es:
PENNACCHIOTTI, GINA ; VALDÉS-GUTIÉRREZ FABIO ; GONZÁLEZ-ARRIAGADA, WILFREDO ALEJANDRO ; MONTES, HÉCTOR FEDERICO ; PARRA, JUDITH ROXANA ; GUIDA, VALERIA ANDREA ; GÓMEZ, SILVINA ESTHER ; GUERRERO-GIMENEZ, MARTIN EDUARDO; FERNANDEZ-MUÑOZ, JUAN MANUEL; ZOPPINO, FELIPE CARLOS MARTIN; CARÓN, RUBÉN WALTER ; EZQUER, MARCELO EDUARDO ; FERNÁNDEZ-RAMIRES, RICARDO ; BRUNA, FLAVIA
Revista:
Scientific Reports
Editorial:
Springer Nature
Referencias:
Lugar: Basingstoke; Año: 2021
Resumen:
The oral squamous cell carcinoma (OSCC), which has a high morbidity rate, affects patients worldwide. Changes in SPINK7 in precancerous lesions could promote oncogenesis. Our aim was to evaluate SPINK7 as a potential molecular biomarker which predicts OSCC stages, compared to: HER2, TP53, RB1, NFKB and CYP4B1. This study used oral biopsies from three patient groups: dysplasia (n = 33), less invasive (n = 28) and highly invasive OSCC (n = 18). The control group consisted of clinically suspicious cases later to be confirmed as normal mucosa (n = 20). Gene levels of SPINK7, P53, RB, NFKB and CYP4B1 were quantified by qPCR. SPINK7 levels were correlated with a cohort of 330 patients from the TCGA. Also, SPINK7, HER2, TP53, and RB1, were evaluated by immunohistofluorescence. One-way Kruskal?Wallis test and Dunn´s post-hoc with a p
