Identification of miRNAs specifically associated with tuberculosis.

SPINELLI, S.V.; FERNANDEZ, R DEL V; BONGIOVANNI, B; DIAZ, A; D'ATTILIO, L; SANTUCCI, N. E.; MARCHESINI, M.M.; BOGUE, C; BAY, M.L.; BOTTASSO, O.A.

Congreso; IV LASID Meeting LXIII Argentinean Immunology Society Meeting II French-Argentinean Immunology Meeting; 2015

miRNAs are important players in host-pathogen interactions. In this study we investigated the role of miR-181, miR-29, let-7 and miR-30 in the pathogenesis of tuberculosis (TB). These miRNA are differentially expressed in blood cells of TB patients and computational analysis of their predicted targets suggests they could be involved in modulating of the immune-endocrine responses observed in TB. In order to correlate miRNA signature with pathology, we employed samples from patients with pulmonary and pleural manifestations of TB as well as from patients with nontuberculous pleurisy. Interestingly, we found that miR-30c expression was strongly repressed in patients with pulmonary TB (p