Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions

AKBAR, ASMA; YANNARELLI, GUSTAVO; ULLAH, MUJIB

TECHNOLOGY IN CANCER RESEARCH & TREATMENT

ADENINE PRESS

Año: 2020 vol. 19

1533-0346

Early detection of cancer has great clinical importance andpotentially improves cure, survival rate and treatment outcome. RNA editingtechnology can be used as targeted and precise molecular scissors to cut andreplace disease-causing genes with healthy ones. This is a post transcriptionalmodification that can lead to the recoding of proteins. RNA editing technologyis in its infancy, but it can be used for early diagnoses and effectivetreatment of cancer. The full potential of precision medicine will be achievedby using the knowledge of RNA reversible-recoding to edit the protein. RNAediting technology could be used to expose chemo resistant cancer cells,dormant cancer stem cells and other malignant tumors. RNA editing generates RNAand protein diversity to accelerate and enhance the screening window for earlydetection of cancer. We propose that the RNA editing sites could be used as anovel tool for early detection of cancer.