Carotid Intima Media Thickness Reference Intervals for a Healthy Argentinean Population Aged 11–81 Years

ZÓCALO, YANINA; LO VERCIO, LUCAS; DIAZ, ALEJANDRO; MANTEROLA, HUGO; DEL FRESNO, MARIANA; BIA, DANIEL; LARRABIDE, IGNACIO; CABRERA FISCHER, EDMUNDO; ZÓCALO, YANINA; LO VERCIO, LUCAS; DIAZ, ALEJANDRO; MANTEROLA, HUGO; DEL FRESNO, MARIANA; BIA, DANIEL; LARRABIDE, IGNACIO; CABRERA FISCHER, EDMUNDO

International Journal of Hypertension

Hindawi Limited

Año: 2018 vol. 2018 p. 1 - 13

2090-0384

Reference intervals (RIs) of carotid intimamedia thickness (CIMT) fromlarge healthy population are still lacking in Latin America.The aimof this study was to determine CIMT RIs in a cohort of 1012 healthy subjects fromArgentina.We evaluated if RIs for malesand females and for left and right carotids were necessary. Second, mean and standard deviation (SD) age-related equations wereobtained for left, right, and average (left + right)/2) CIMT using parametric regression methods based on fractional polynomials,in order to obtain age-specific percentiles curves. Age-specific percentile curves were obtained. Males showed higher A-CIMT(0.577 ± 0.003mm versus 0.566 ± 0.004 mm, 𝑃 = 0.039) in comparison with females. For males, the equations were as follows:A-CIMT mean = 0.42 + 8.14 × 10−5 ∗Age2; A-CIMT SD = 5.9 × 10−2 + 1.09 × 10−5 ∗Age2. For females, they were as follows: A-CIMTmean = 0.40 + 8.20 × 10−5∗Age2; A-CIMT SD= 4.67 × 10−2 + 1.63 × 10−5∗Age2.Our study provides the largest database concerningRIs of CIMT in healthy people in Argentina. Specific RIs and percentiles of CIMT for children, adolescents, and adults are nowavailable according to age and gender, for right and left common carotid arteries.