THE THYROID STATUS MODULATES THE COMPOSITION OF TUMOR MICROENVIRONMENT AND THE ANTITUMOR IMMUNE RESPONSE IN A 4T1 MURINE BREAST CANCER MODEL

HILDEBRANDT X; BOLONTRADE M; GARCÍA M; STERLE HA; PAULAZO MA; CREMASCHI GA

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Several findings suggest that the patient?s hormonal context plays a crucial role in determining the outcome of cancer. However, very little is known about the nature of thyroid hormone action on tumor growth. Our aim was to evaluate the effect of thyroid status on the immunity and microenvironment of breast cancer. For this, Balb/c mice were orthotopically inoculated with 4T1 breast carcinoma cells after the treatment with thyroxine (12mg/l) for 30 days or propylthiouracil (500mg/l) for 15 days in the drinking water to obtain hyperthyroid (hyper) or hypothyroid (hypo) mice, respectively. An increased tumor growth rate was seen in hyper mice compared to controls (p