Chemotherapy-induced changes in the expression of transient potential receptors in dorsal root ganglia and spinal cord in both male and female animals: implications for neuropathic pain generation

M.V. NOYA-RIOBÓ; M.J. VILLAR; M.A. ZAPATA VACA; M.F. CORONEL; C.A. MIGUEL; F.B. SBERNA

Córdoba

Congreso; Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias; 2021

Sociedad Argentina de Investigación en Neurociencias

Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a frequent and debilitating side effect of cancer therapy. Transient potential receptors (TRPs) are non-selective cation channels involved in the detection of thermal, chemical and mechanical stimuli and in the neurotransmission of pain. Their role in CIPNP has recently begun to be explored, as well as the existence of sex differences in pain behaviors in animals receiving chemotherapy. Here we evaluated the development of mechanical and cold allodynia in animals exposed to oxaliplatin, analyzing the existence of sex-related differences, as well as changes in the expression of TRPV1, TRPM8 and TRPA1 in the dorsal root ganglia (DRGs) and spinal cord (SC). Animals were injected with oxaliplatin, allodynia was evaluated using von Frey and Choi tests, and the mRNA levels of TRPs were evaluated by real time RT-PCR. Oxaliplatin administration induced the development of mechanical and cold hypersensitivity and allodynia in both male and female animals (p