IBIOMAR - CENPAT 25620
INSTITUTO DE BIOLOGIA DE ORGANISMOS MARINOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
PROGESTERONE RECEPTOR ISOFORM RATIO DICTATES ANTIPROGESTINS/PROGESTINS EFFECTS ON METASTATIC BREAST CANCER MODELS
Autor/es:
ABASCAL, MARIA FLORENCIA; VANZULLI, SILVIA; GIBBONS, LUZ; BURRUCHAGA, JAVIER; SEQUEIRA, GONZALO; PATACCINI, GABRIELA; MARTINEZ VAZQUEZ, PAULA; LANARI, CLAUDIA; ALVAREZ, MICHELLE MARILYN; ELIA, ANDRES; GASS, HUGO; GIULIANELLI, SEBASTIÁN
Lugar:
Mar del Plata
Reunión:
Congreso; REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIA 2019; 2019
Institución organizadora:
SAIC
Resumen:
The role of the progesterone receptor isoforms A (PRA) and B (PRB) in breast cancer (BC) is still controversial as well as the use of PR ligands for BC treatment. Our aim was to evaluate a) the role of PRA and PRB in metastaticgrowth, b) the effect of different progestins (P) and antiprogestins (AP) in metastatic models c) the involvement of two metastasis suppressor genes, NDRG1 and NME1. Mifepristone and 3 other AP inhibited the onset and growth of lymph node and lung metastases of the murine C7-2-HI tumor with PRA>PRB (PRA-H). Whentumors were removed, and the long-term metastasis were evaluated after interruption of AP neoadyuvant/adjuvant treatment, an increase in disease free survival rate was observed in all AP-treated mice as compared to controls (p
