Volumetric correlation between parkinsonian signs and primary progressive aphasia subtypes

PONTELLO NOELIA; FERRARI JESICA; MANES FACUNDO; CORDERO, INDIRA GARCÍA; MARTÍNEZ CUITIÑO MACARENA; BOROVINSKY GERALDINE; COUTO BLAS

Simposio; Buenos Aires AAIC Satellite Symposium Alzheimer's Association; 2018

Primaryprogressiveaphasia(PPA)ischaracterizedpredominantlybyalinguisticimpairment.RecentandpreviousevidencehaveshownthepresenceofparkinsonisminpatientswithdiagnosisofPPA.FurtherevidencecharacterizesdifferentialatrophypatternsoftheclinicalsubtypesofPPA:nonfluent(PNFA),semanticdementia(SD)andlogopenic(PLA).Theaimofthisstudyistodeterminetheprevalenceofparkinsoniansignsinthe3variantsofPPAandtoinvestigatetheassociationofPPAatrophyandtheseparkinsoniansigns.assessment.WefoundnodifferencesinageandgenderbetweenPPApatients(average69DS5,17;32%masc)andcontrols(average68,5DS6,01;37%masc).BesidestheresultsshowednodifferencesamongPPAsubtypesinyearsofevolution,ageandtotalUPDRSscore.