The effect of prenatal social interactions on pre and postnatal neurodevelopment

CASTRO A; FLORES V*; RODRIGUEZ GONZALEZ M; PIROLA D; RAPACIOLI M*; ARENAS VALERIOTI J; CANET Z

CABA

Congreso; SAN2022 Meeting - XXXVII SAN Annual Congress; 2022

Sociedad Argentina de Investigación en Neurociencias

Chick embryo development can be accelerated by means of sounds (clicks), produced by more advanced embryos, transmitted by eggshell contact. We analyzed whether click-mediated actions affect cell proliferation, hormonal profile, and postnatal behavior. Cell proliferation was evaluated on day 1 after hatching in the ventricular and subventricular areas of the pallium cephalic region on (1) accelerated group, (2) incubated in isolation, and (3) incubated in contact. Globally considered, no differences were found between groups in the ventricular area, but higher mitotic densities were observed in the nidopallium of the group 2 and in the medial striatum of the group 1. A higher global mitotic density was found in the subventricular area in group 1, explained exclusively by differences found in the medial striatum. Hormones were assayed at hatching and 33 days after hatching. At hatching, the group 1 displayed values of T3 and TSH higher than controls. The differences disappear 33 days after hatching. Postnatal behavior was evaluated on groups 1 and 3. No differences were found in the performance shown in the ?T-maze? test. In the ?order of passage through the door? dominance-test, however, in both groups, males passed before than females. Besides, males of group 1 display lower average order than those of group 3. These results will help to better understand the effects of prenatal interactions on neural development.