Synthesis and characterization of fumarate copolymers-based membranes for transdermal release

MAGALÍ PASQUALONE; M. SUSANA CORTIZO; H. ALFREDO ANDREETTA

Vina del Mar

Taller; 3 er Taller de Órganos Artificiales, Biomateriales e Ingeniería de Tejidos; 2013

Sociedad Latinoamericana de Organos Artificiales, biomateriales e Ingenieria de tejidos

Over the last years, an extensive research effort has been directed toward developing membranes to specific biomedical applications. In particular are of interest the transdermal drug delivery system (TDDS) whereby the drug, incorporated into a patch, is released through the skin to effect a pharmacological action at a location or locations remote from the site of action. In contrast to others delivery systems, TDDS is especially useful for delivery drugs which present gastrointestinal problems, such as some of those used in the treatment of bone diseases. In this work, we present the results of synthesis of new fumarate copolymers, membrane preparation and characterization. Radical copolymerization of vinyl acetate (VA) with Di-(octan-2-yl) fumarate (DOF) was carried out in bulk, initiated by benzoyl peroxide under microwave energy (140W, 4 min), following the methodology previously reported. The products were characterized by 1H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on this copolymer two membranes supported on polyvinyl alcohol were prepared and their morphology and mechanical properties were studied.