PERSONAL DE APOYO
SOAJE Marta
congresos y reuniones científicas
Título:
Hyperthyroidism alters mamary glands development during lactation and impairs offspring nutrición.
Autor/es:
SANCHEZ MB; MITCHEL MC; VIRUEL, L.B.; NEIRA, F. J.; RODRÍGUEZ-CAMEJO C; PIETROBON EO; SOAJE, M.; HERNANDEZ A.; JAHN, G.A.; VALDEZ SR; MACKERN-OBERTI JP
Lugar:
Mendoza
Reunión:
Congreso; XL Reunión Científica Anual de la Sociedad de Biología de Cuyo.; 2022
Institución organizadora:
Sociedad de Biología de Cuyo
Resumen:
Maternal milk is a great source of bioactive components, immune factors, hormones, and nutrients which are vital for the development of the newborns. Hyperthyroidism (H) alters maternal behavior and disrupts milk production. However, it remains unclear if H could generate changes in the nutritional and immunological composition of maternal milk. Our work aimed to evaluate the influence of H on milk quality and bioactive components and if this affects developmental and immunological parameters of offspring in early lactation. To this end, 12 weeks old Wistar rats were injected with 0,25 mg/kg T4 (hyper) and vehicle (control) and euthanized on day 2 of lactation (L2). Serum, milk, and mammary gland from dams and offspring serum were obtained for further analysis. Total IgG and IgA levels from mothers and offspring serums and rat milk were analyzed by ELISA. Nutritional components like total proteins, reducing sugars (lactose), caloric value, and fat content was measured in milk. Moreover, histological analysis of the mammary gland was performed and offspring developmental, biochemical, and hormonal parameters were evaluated on L2. Our results show that H pups had lower weight on days 1 and 2 (p