PERSONAL DE APOYO
SOAJE Marta
congresos y reuniones científicas
Título:
LEUKOCYTES INFILTRATION CHAPERONES HYPERTHYROIDISM-INDUCED INCREASE OF FETAL GROWTH, PLACENTAL CHANGES, AND IMPAIRED OFFSPRING DEVELOPMENT
Autor/es:
SANCHEZ MB; NEIRA FJ; MORENO-SOSA MT; MITCHEL MC; PIETROBON EO; SOAJE M; JAHN GA; VALDEZ SR; MACKERN-OBERTI JP
Lugar:
Buenos Aires
Reunión:
Congreso; LXVI ANNUAL MEETING OF SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2021
Institución organizadora:
Sociedad Argentina de Investigación Clínica (SAIC)
Resumen:
Hyperthyroidism (HP) induces reproductive disorders like preterm birth and lactation failures and could influence immune cells homeostasis. Therefore, our work aimed to evaluate the role of thyroid hormones in leukocytes in milk and placenta. To this end, 12 weeks old Wistar rats were injected with T4 (hyper) and euthanized on day 19, 20 of gestation (G19 and G20), and day 2 of lactation (L2). Placenta and milk immune cells (CD45+, CD3+, CD11b/c+) were analyzed by flow cytometry, and mRNA hormone receptors and cytokines by qPCR. Histological analysis of the mammary gland was performed. We observed that fetuses of hyper group (hyper) weighed more in G19 and G20 (p
