Expression of dopamine receptors in PBMC from patients with pulmonary or pleural tuberculosis. A potential adverse profile

DÍAZ ARIANA; SANTUCCI, NATALIA; LIOI, SUSANA; FERNÁNDEZ, ROCÍO DEL VALLE; BONGIOVANNI, BETTINA; GARDEÑEZ, WALTER; BAY, MARIA L.; D'ATTILIO, LUCIANO; IMOHFF MATILDE; BÉRTOLA, DIEGO; BOTTASSO, OSCAR

Buenos Aires

Congreso; Reunión conjunta de Sociedades de Biociencias y 65ta Reunión de la SAI; Buenos Aires, 13-17 Noviembre 2017; 2017

Reunión Conjunta de Sociedades de Biociencia

Tuberculosis (TB) is the second cause of death worldwide, mostly affecting the lungs (pulmonary TB, PTB), although pleural tuberculosis(PLTB) can be a frequent extrapulmonary manifestation.The immune system receives and sends messages to the centralnervous system modulating each other through the HypothalamusPituitary Adrenal axis and the autonomous nervous system (ANS).When studying patients with PTB or PLTB we have recently shownthat both patients groups had increased dopamine plasma levels. Toextend this observation and mainly because dopamine effects arestrongly dependent on the types of receptors expressed by targetcells, we have now analyzed the expression of transcripts (qRTPCR)for the dopamine receptors (DRs) of type 1 (DR-1 and DR5,both mediating inhibitory effects) and type 2 (DR-2, DR-3 and-DR4;mostly stimulating) in peripheral blood mononuclear cells (PBMC) ofpatients with PTB (n = 18) and PLTB (n = 12) and healthy controls(HCo; n=16). Both patient groups showed a significant decrease inthe transcripts for DR-3 and DR4 (p