Antibody profiles induced by T. cruzi in chagasic patients with previous or current exposure to mycobacteria

PROCHETTO, ESTEFANÍA; MARCIPAR, IVAN; RODELES, LUZ; PEVERENGO, LUZ; BOTTASSO, OSCAR; VALENZUELA, JOSÉ IGNACIO; VICCO, MIGUEL

Pathogens and Disease

Federation of European Microbiological Societies

Año: 2016 vol. 74

Since the immune response mounted by the host to a particular microorganism might be influenced by the acquired immunological experience due to previous contact with other microorganism, we performed a cross-sectional study to explore the pattern of T. cruzi-infection related antibodies in T. cruzi-seropositive individuals presenting concomitant tuberculosis, or the antecedent of BCG vaccination. Sampled individuals were grouped as follows: patients with Chagas disease, not vaccinated with BCG, who further developed pulmonary tuberculosis; individuals with Chagas disease BCG-vaccinated; and subjects with Chagas disease, presenting neither BCG scar nor tuberculosis disease. Nonvaccinated individuals or without tuberculosis, presented the highest values of anti-PH (p