Hv1 increased activity is asssociated to a high glycolitic flux

VENTURA C; FELICE JI; MILESI V; ENRIQUE N; ISSOURIBEHERE D; MARTIN P; ASUAJE A

Congreso; LXV REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2020

SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC)

It is well-known that most of cancer cells present an increased glycolytic flow related to their metabolic reprogramming (Tanner et al., 2018). This metabolic change, considered an emerging hallmark of cancer, conduces to an exacerbated lactate secretion and produces large amounts of protons. We have previously demonstrated that the inhibition of Hv1, an ion channel capable to extrude H+ of cells, induces intracellular acidification and apoptosis in leukemic Jurkat T cells (Asuaje et al., 2018). In this work we present evidences showing that Jurkat T cells cultivated in presence of high (25 mM) glucose concentration increases (15%, p