Direct evidence for local IgE production in the human colonic mucosa

GUZMAN, LUCIANA; ALTAMIRANO, EUGENIA MARGARITA; CANZIANI, KARINA EVA; BERNEDO, VIVIANA; MUGLIA, CECILIA ISABEL; PUCCI MOLINERIS, MELISA; GARCÍA, MARCELA; DOCENA, GUILLERMO HORACIO

ALLERGY - EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Wiley-Blackwell Publishing Ltd

Lugar: Zurich; Año: 2020

1398-9995

Ambos últimos autores compartimos Senior AuthorshipUnderstanding the biology of IgE in humans has become a matter of interest that remains incompletely understood due to the rarity of peripheral IgE+ cells. The increased incidence of allergic diseases and food-induced anaphylaxis overtime demands an urgent development of disease-modifying therapies that reverse the synthesis of IgE and the induction of IgE-mediated allergic reactions. Although some reports showed specific IgE in stools and IgE+ cells in the gastrointestinal tract of allergic patients,1,2 the microanatomical location of the class-switch recombination (CSR) to ε chain is largely unknown. Our study aimed to investigate the local IgE synthesis in the stroma of juvenile colonic polyps (JP) from patients with rectal bleeding and the relationship between IgE production and food sensitization, a risk factor for food allergy.This study showed direct evidence that the colorectal mucosa confined to colorectal polyps from patients sensitized to food allergens constitutes a tertiary lymphoid tissue containing active germinal centers with ongoing IgE synthesis through direct and sequential class-switch recombination mechanisms. Therefore, we suggest that there could be an association between rectal bleeding and colorectal polyps with allergen sensitization.