Your environment defines you: The effects of environmental stimulation over the brain in an early obesity rat model.

CANESINI, G.; GAYDOU, L.; ROSSETTI, M.F; SCHUMACHER, R.; ANDREOLI MF; FABRE, N.; STOKER, C.; RAMOS, J.G

Congreso; SAN 2020; 2020

Early obesity has been related to changes in the normal structure and function of the brain, exacerbating neurodegenerative processes and producing alterations over cognition. Environmental stimulation can intensify or attenuate these changes. Our group has previously found that small litters model (SLM) produces an early obesity state (postnatal day 21; PND21), increasing body weight, body percentage of epididymal adipose tissue (EAT), and blood concentrations of glucose, cholesterol, and triglycerides. At medium-term (PND90), SLM produces an increased TAE and alterations in episodic memory, while body weight and blood metabolites normalize. In this work, we analyzed the medium-term effects of an enriched environment over the brain in an SLM.