IMPACT OF THE GHRELIN SIGNALING ON FOOD INTAKE AFTER A FASTING EVENT

GIMENA FERNÁNDEZ, AGUSTINA CABRAL, ALEXANDRA LABARTHE, GUADALUPE GARCÍA ROMERO , M. FLORENCIA ANDREOLI, FLORENCIA ACUTAIN, MIRTA REYNALDO, GUILLERMO RAMOS 3 , VIRGINIE TOLLE, EPELBAUM JACQUES , MARIO PERELLÓ

Buenos Aires

Congreso; 2d FALAN CONGRESS; 2016

Refeeding after a period of severe fasting triggers a robust hyperphagia, which persists even after animals have reached their energy needs. Plasma ghrelin levels and the hypothalamic gene expression of the ghrelin receptor (or growth hormone secretagogue receptor, GHSR) increase during fasting in order to cope with the negative energy balance condition. Here, we investigated the potential modulatory role of the ghrelin system on the compensatory hyperphagia that display mice that have been exposed to a 48h fasting period.