Glyphosate based herbicide exposure may exacerbate endometrial hyperplasia induced by cafeteria diet in adult rats

LORENZ V; MILESI MM; DURANDO M; ZANARDI MV; GUERRERO SCHIMPF M; ZIERAU O; GASTIAZORO MP; ALMIRÓN A; VARAYOUD J

Modalidad Virtual

Congreso; Reunión Anual de Sociedades de Biociencias SAIC SAI SAFIS 2021; 2021

Many lifestyle factors can predispose to the development of endometrialcarcinoma (EC). Previously, in rats, we detected that: a)cafeteria diet (CAF) induced endometrial hyperplasia (EH), a precursorlesion of EC; b) exposure to glyphosate-based herbicide(GBH) altered uterine development causing EH and increased cellproliferation. In the present work we sought to evaluate whetherthe exposure to a low-dose of a GBH plus CAF diet might enhancethe uterine morphological alterations induced by CAF diet alone.Female Wistar rats were fed from postnatal day 21 (PND21) untilPND240 with: chow diet (CON) or CAF. At PND140 one group ofrats feed with CAF also received GBH through food, yielding 3 experimentalgroups: CON; CAF; CAF+GBH. Rats were sacrificed atPND240 and serum, fat depots, and uterine samples were obtained.Data were analyzed by Kruskal?Wallis followed by Mann-Whitneypost-test (p