Neural mechanism involved in contextual memory: role of CA3 and CA1 remapping

MARIANO BELLUSCIO; AZUL SILVA; PEDRO BEKINSCHTEIN

Congreso; XXXIV Congreso Anual Sociedad Argentina de Investigación en Neurociencias 2019; 2019

TheHippocampus (HP) is involved in encoding, consolidation and retrievalof episodic memories. Some hippocampal neurons, place cells (PC) aretuned to spatial location and generally change their tunning when ananimal change context (remapping). It has been suggested that thehippocampal ability of storing and distinguishing between differentsituations and contexts can be related with place cell?s remapping.Severalstudies have shown how PC can either remap or not as a consequence ofchanges in the environment. It is also known that there aredifferences between CA1 and CA3 (two hippocampal regions) in spatialcodification. Still, there is no study showing the link between thememory that the animal is expressing and the activity of its neurons.In other words, It?s still unknown whether when an animalrecognizes a certain context as new, there is remapping in the HP ornot.The aim of this project is to understand how thedifferential remapping observed in CA1 and CA3 correlates with thebehavioral response. To answer this question we use A behavioral taskthat allowed us to discriminate if an animal recognizes a context asnew, or as one they already knows. We carried outelectrophysiological recordings in CA3 and CA1 region of the HP whilethey were performing the tasks in order to correlate the remappingand the evocation of different contexts. p { margin-bottom: 2.12mm; direction: ltr; color: rgb(0, 0, 0); background: transparent none repeat scroll 0% 0%; }p.western { font-family: "Times New Roman", serif; font-size: 12pt; }p.cjk { font-family: "SimSun", "宋体"; font-size: 12pt; }p.ctl { font-family: "Lucida Sans", sans-serif; font-size: 12pt; }