Consolidation of adaptation memories depend both on the passage of time and sleep

A. SOLANO, G. LERNER, P. CAFFARO, L. A. RIQUELME, D. PEREZ CHADA, V. DELLA MAGGIORE.

San Diego, CA

Congreso; Annual meeting of the Society for Neuroscience; 2022

SFN

Strong evidence suggests that declarative memories benefit from sleep. However, its contribution to motorlearning is controversial. Motor skill learning (MSL), such as performing a sequence of finger movements explicitly, isbenefited by sleep [1] whereas the available evidence on sensorimotor adaptation (SMA) suggests thatconsolidation depends exclusively on the passage of time [2,3,4]. These studies generally track memory retentionafter a time interval containing or not a period of sleep, but disregard the time elapsed between training and sleep asa potentially relevant factor. Here, we tested the hypothesis that the temporal proximity of these events is critical forsleep consolidation of SMA. To this aim, we examined the impact of manipulating the time interval elapsed betweenvisuomotor adaptation learning (VMA) and sleep on long-term memory (LTM) and on the neural markers of sleepconsolidation [5].With the aim of confirming the results from previous studies [2,3,4] with our experimental paradigm, inExperiment 1 we examined the effect of sleep on VMA when the time elapsed between training and sleep was nottaken into account. To this aim, we tracked memory decay as a function of the passage of time, and examined theimpact of a full night of sleep on memory retention. 134 subjects randomly assigned to 6 groups adapted to anoptical rotation (CCW-30º), and underwent a memory retention test with error-clamp (EC) trials at different timeintervals post learning (Fig 1A; 15 min, 1 h, 3 h, 5.5 h, 9 h, or 24 h). Critically, the time of training was notmanipulated. As observed in Figure 1B (left panel), memory retention decayed with the passage of time (ANOVA,F(5,128)=13.75, p