The febrile response to intraperitoneal lipopolysaccharide: strain and gender differences in rats

TAYLOR, A.N., TIO, D.L., AND ROMEO, H.E

JOURNAL OF NEUROIMMUNOLOGY

Año: 2005 vol. 158 p. 86 - 93

0165-5728

The acute-phase febrile responses of the inbred Lewis (LEW) and Fischer 344 (F344) rat strains and their parent Sprague-Dawley (S-D) strain to immune challenge with lipopolysaccharide (LPS) were compared. LEW and S-D males and females displayed a biphasic febrile response with a markedly attenuated second phase in F344 rats. At 2 h after LPS (50 microg/kg), corticosterone was significantly higher in F344 than in LEW rats, but serum interleukin-1beta was higher only in F344 than LEW males. These data suggest that the greater LPS-induced corticosterone response of F344 rats mediates differences between febrile responses of F344 and LEW males and females.