BIOMED   24552
INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Unidad Ejecutora - UE
artículos
Título:
Should we listen to our clock to prevent type 2 diabetes mellitus?
Autor/es:
KARTHIKEYAN R; MARIMUTHU G; SPENCE DW; PANDI-PERUMAL SR; BROWN GM; CARDINALI DP
Revista:
DIABETES RESEARCH AND CLINICAL PRACTICE
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Lugar: Amsterdam; Año: 2014 vol. 106 p. 182 - 190
ISSN:
0168-8227
Resumen:
the circadian clock drives a number of
metabolic processes including energy intake, storage and utilization coupled
with the sleep/wake cycles. Globally, the increasing prevalence of type 2
diabetes (T2DM) has become a significant international public health concern.
In view of the heavy societal burden caused by diabetes, and further, to reduce
its growing incidence, it is clearly essential to understand the causes of this
disease and to devise more effective strategies for its treatment. Although
many factors cause T2DM, this article centers on the role of circadian
regulation of metabolism. The correlation between the increased occurrence of
T2DM and the ubiquity of modern social pressures such as 24/7 lifestyles as
well as nocturnal lighting conditions point strongly to the hypothesis that
malfunctioning of circadian controls may be involved in the etiology of the
illness. Nocturnal light exposure, unusual timing of food, irregular sleep/wake
schedules and traveling between different time zones are some of the factors
responsible for improper entrainment of the clock. Recent reports have proposed
that strengthening of circadian clock functioning and proper timing of food
intake could stabilize glucose homeostasis. This strategy thus represents a
chronotherapeutic option for non-pharmaceutical intervention in treating T2DM
patients.