Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease.

SÁNCHEZ, STELLA-MARIS; VÁZQUEZ, SILVIA; FIORENTINI, LETICIA; ABULAFIA, CAROLINA; SEVLEVER, GUSTAVO; VILLARREAL, MIRTA F.; DUARTE-ABRITTA, BÁRBARA; GUSTAFSON, DEBORAH R.; CASTRO, MARIANA N.; GUINJOAN, SALVADOR M.

PSYCHIATRY RESEARCH: NEUROIMAGING

ELSEVIER IRELAND LTD

Año: 2021 vol. 316

0925-4927

Atraditionalhallmarkofcognitiveimpairmentassociatedwithlate-onsetAlzheimer ́sdisease(LOAD)isepisodic memory impairment. However, early alterations have been identi ed in brain regions associated with executive function in asymptomatic, middle-age offspring of patients with LOAD (O-LOAD) compared to those with no family history. We hypothesized that executive function among O-LOAD would correlate with structural and amyloid brain imaging differently from those without a family history of LOAD (control subjects, CS). Executive function, cortical thickness, and in-vivo Aβ deposits were quanti ed in 30 O-LOAD and 25 CS. Associations were observed among O-LOAD only. Cortical thickness in the left lateral orbitofrontal cortex was positively associated with Design Fluency. The Stroop Color and Word Test, correlated positively with right rostral mid-frontal cortex thickness. Trails Making Test-B was inversely related to left medial orbitofrontal thickness. Tower of London total time was positively associated with β-amyloid deposition in the right precuneus. These results support previous evidence that early executive dysfunction might re ect subtle, early changes in persons at risk of LOAD and suggests that executive function alterations deserve further exploration in the LOAD literature.