Skin resident CD4negCD8neg (double-negative) T cells produce IL-17A during Nannizia gypsea dermatophytic infection

BECCACECE IGNACIO; BURSTEIN VL; ALMEIDA, MARIEL A.; GUASCONI, LORENA; MENA, CRISTIAN J.; CHIAPELLO LAURA S.

Mar del Plata

Jornada; REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIAS. LXX REUNION ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA-SAI & 3rd FRENCH-ARGENTINE IMMUNOLOGY CONGRESS; 2022

Sociedad Argentina de Inmunología (SAI)

Dermatophytosis is a highly prevalent superficial fungal disease that affects keratinized tissues such as the skin, hair and nails. Despite the high prevalence of this fungal disease worldwide the immune response against dermatophytes is still not completely understood. We have previously reported that type-17 immunity is crucial for controlling the Nannizzia gypsea infection by limiting fungal overgrowth in the epidermis. Deficiencies in IL-17A or its activity through IL-17RA leads to exacerbated skin inflammation and a shift to an IFN-γ-mediated response. In addition, we have shown that IL-17A is produced by skin resident γδT and αβT cells and this response is independently of the influx of T lymphocytes from draining lymph nodes. Furthermore, the single depletion of γδT cells does not lead to increased susceptibility since IL-17A production by epidermal cells is not abolished. Nevertheless, the origin and function of IL-17A-producing αβT cells during dermatophytosis remains to be clarified.