Study of the phenotype of peripheral T, B and NK cells and systemic profile of soluble immune mediators in HIV+ people who have undergone SARS-CoV-2 infection

MARÍA BELÉN VECCHIONE; MARÍA LAURA POLO; BBEI WORKING GROUP; MARIA FLORENCIA QUIROGA; ALEJANDRO CZERNIKIER; VIRGINIA GONZALEZ POLO; YESICA LONGUEIRA; NATALIA LAUFER; DENISE GIANNONE; LEONEL CRUCES; YANINA GHIGLIONE; GABRIELA TURK

Virtual

Congreso; Reunión Conjunta de Sociedades de Biociencias 2021; 2021

Sociedad Argentina de Inmunologia

The immune response to SARS CoV‐2 in people living with HIV (PLWH) has not yet been fully elucidated. Our aim was to investigate the impact of HIV infection on cell populations and cytokines/chemokines involved in the SARS CoV-2 immune response. We investigated by flow cytometry the phenotype of circulating T, B, NK cells and monocytes, as well as the plasma concentration of cytokines and chemokines in both 29 PLWH on HAART and 33 HIV-negative (HIVneg) persons. Subjects were studied during convalescence of SARS-CoV-2 infection. Data were analyzed using non-parametric tests and considered statistically significant when the p values were 0.05) among PLWH compared to HIVneg, despite similar proportions (%) of B cells between the groups. Both groups presented similar % of Th1, Th17, Th1/Th17 and Tregs. Likewise, PLWH showed an increased % of total (p