Galectin-1 promotes HIV-1 latency reactivation

GABRIEL DUETTE; SALIDO, JIMENA; ALAN ADAMCZYK; NATALIA LÄUFER; MATIAS OSTROWSKI; JULIA RUBIONE; PEHUEN PEREYRA GERBER; LUCIA GUZMAN; YANINA GHIGLIONE; GABRIEL A. RABINOVICH; PEREZ, PAULA S.; ALEJANDRO CAGNONI; SUED, OMAR; KARINA V. MARIÑO

Congreso; IAS Conference 2019; 2019

Galectin-1 (Gal-1) is an endogenous lectin with impor-tant immunomodulatory functions acting on both innate and adaptive immune cells. HIV-1 infects manly cD4+ t lymphocytes and mac-rophages causing cD4+t cell depletion, ultimately leading to acquired immunodeficiency syndrome (aIDs). Implementation of combination antiretroviral therapy (cart) significantly improves the prognosis of HIV-infected individuals. Nevertheless, chronic inflammation and the maintenance of latently infected cells-viral reservoir- represent two major barriers to achieve the cure of HIV infection. Herein, we analyzed the role of Galectin-1 on HIV-1 latency reactivation and chronic immune activation.